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Sigrima Pertuzumab 420 Mg Injection

Sigrima Pertuzumab 420 mg Injection is a targeted anti-cancer medicine used primarily in the treatment of HER2-positive breast cancer. It contains Pertuzumab, a monoclonal antibody that works by blocking the HER2 receptor, which is responsible for the growth and spread of cancer cells. It is often used in combination with other chemotherapy medicines to improve treatment outcomes.

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Composition and Content

Active Ingredient: Pertuzumab
Strength: 420 mg per vial
Formulation: Sterile solution for intravenous infusion
Drug Class: Monoclonal Antibody (HER2 inhibitor)

How It Works

Pertuzumab targets the HER2 receptor on cancer cells and prevents them from pairing with other HER receptors. This action blocks cell signaling pathways that promote cancer cell growth and survival, thereby slowing or stopping tumor progression.

How to Use

Administered as an intravenous (IV) infusion under medical supervision
Usually given in a hospital or oncology clinic
Often combined with Trastuzumab and chemotherapy drugs (like docetaxel)
The infusion duration and frequency depend on the treatment plan prescribed by an oncologist

Dosage

Initial Dose: 840 mg IV infusion
Maintenance Dose: 420 mg every 3 weeks
Dosage adjustments may be required based on patient condition and tolerance

Uses

Sigrima Pertuzumab is indicated for:

HER2-positive metastatic breast cancer
Early-stage HER2-positive breast cancer (neoadjuvant/adjuvant therapy)
Combination therapy with other HER2-targeted agents

Treatment Benefits

Improves survival rates in HER2-positive breast cancer patients
Reduces tumor size before surgery
Helps prevent recurrence when used in early-stage cancer
Enhances effectiveness when combined with other targeted therapies

Advantages

Targeted therapy with fewer effects on healthy cells
Proven efficacy in combination regimens
Suitable for both early and advanced stages of breast cancer
Well-established safety and effectiveness profile

Storage Conditions

Store in a refrigerator at 2°C to 8°C
Do not freeze
Keep in original packaging to protect from light
Use immediately after dilution or as directed by healthcare provider

Alternative Indian Brands

Some commonly available alternatives containing Pertuzumab include:

Perjeta (Pertuzumab) – by Roche
Biosimilar Pertuzumab brands available from Indian pharmaceutical manufacturers (subject to availability)