Stelara (Ustekinumab 90 mg Injection)
Ustekinumab 90 mg Injection (marketed as Stelera/Stelara) is a biologic medication used to treat autoimmune and inflammatory conditions. It works by targeting specific proteins in the immune system (IL-12 and IL-23), helping reduce inflammation and prevent disease progression.
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Composition and Content
- Active Ingredient: Ustekinumab
- Strength: 90 mg per prefilled syringe or vial
- Form: Solution for subcutaneous injection
- Class: Human monoclonal antibody (Immunosuppressant)
How to Use
- Administered as a subcutaneous injection (under the skin).
- Given by a healthcare professional or self-administered after proper training.
- Injection sites: abdomen, thighs, or upper arms.
- Follow strict aseptic techniques.
Dosage
Dosage varies based on the condition:
- Psoriasis / Psoriatic Arthritis:
- Initial dose → Week 0
- Second dose → Week 4
- Maintenance → Every 12 weeks
- Crohn’s Disease / Ulcerative Colitis:
- Initial IV induction dose (weight-based)
- Followed by 90 mg SC every 8 weeks
Note: Always follow your doctor’s prescription.
Uses
Ustekinumab 90 mg Injection is used in the treatment of:
- Moderate to severe plaque psoriasis
- Psoriatic arthritis
- Crohn’s disease
- Ulcerative colitis
Treatments & Mechanism of Action
- Blocks interleukin-12 (IL-12) and interleukin-23 (IL-23) proteins
- Reduces immune system overactivity
- Helps control inflammation and autoimmune response
- Improves symptoms like skin lesions, joint pain, and gastrointestinal inflammation
Advantages
- Long dosing interval (every 8–12 weeks)
- Targeted therapy with fewer systemic side effects
- Effective for patients not responding to conventional therapies
- Improves quality of life significantly
- Suitable for chronic autoimmune conditions
Storage Conditions
- Store in a refrigerator at 2°C to 8°C
- Do not freeze
- Keep in original packaging to protect from light
- Do not shake the injection
- Keep out of reach of children
Alternative Indian Brands
Some alternatives available in India (consult doctor before switching):
- Stelara (Janssen) – Original brand
- Ustekinumab Biosimilars (availability may vary in India):
- Azelinumab (emerging biosimilar)
- Ustebiosimilar brands by Indian manufacturers (subject to regulatory approval)
Note: Biosimilars availability in India is evolving; always verify with a healthcare provider.
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