REPATHA (Evolocumab 140 mg/mL) Injection
Evolocumab is a monoclonal antibody belonging to the PCSK9 inhibitor class, used to significantly lower LDL cholesterol (bad cholesterol) in patients at high risk of cardiovascular disease. REPATHA (Evolocumab 140 mg/mL) Injection helps the liver remove LDL cholesterol more efficiently from the bloodstream, thereby reducing the risk of heart attack, stroke, and other cardiovascular complications.
It is commonly prescribed for:
- Primary hyperlipidemia
- Familial hypercholesterolemia (genetic high cholesterol)
- Established cardiovascular disease requiring intensive LDL reduction
This medicine is given as a subcutaneous injection under medical supervision.
Contact Details for Orders
💬 WhatsApp: +91 9730316395
📞 Phone: +91 9730316395
📧 Email: info@globmedindia.com
Composition and Content
- Active Ingredient: Evolocumab
- Strength: 140 mg/mL
- Dosage Form: Pre-filled syringe / auto-injector pen
- Category: PCSK9 inhibitor (biologic lipid-lowering therapy)
How It Works (Mechanism of Action)
Evolocumab works by:
- Blocking the PCSK9 protein in the bloodstream
- Increasing LDL receptor availability in the liver
- Enhancing clearance of LDL cholesterol
- Producing sustained and significant LDL reduction
Uses and Treatments
REPATHA (Evolocumab) Injection is used for:
- High LDL cholesterol (hypercholesterolemia)
- Familial hypercholesterolemia (genetic condition)
- Patients not responding adequately to statins
- Prevention of cardiovascular events (heart attack, stroke)
- Secondary prevention in patients with existing heart disease
Dosage and How to Use
- Administered as a subcutaneous injection
- Standard dosing:
- 140 mg every 2 weeks OR
- 420 mg once monthly
- Injection sites: abdomen, thigh, or upper arm
- Must be used under physician supervision
⚠️ Do not change dosage without medical guidance.
Advantages
- Strong LDL cholesterol reduction (up to 60%+)
- Reduces risk of heart attack and stroke
- Effective for statin-intolerant patients
- Convenient dosing schedule
- Proven cardiovascular benefit in clinical studies
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze
- Keep in original packaging
- Allow to reach room temperature before use
- Protect from light and heat
Alternative Brands / Similar Medicines
Currently, Evolocumab is primarily available as:
- Repatha – by Amgen
Other cholesterol-lowering biologic alternatives include:
- Praluent (Alirocumab) – by Sanofi
- Leqvio (Inclisiran) – by Novartis
These are prescribed based on lipid profile and physician evaluation.
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