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Enhertu (Trastuzumab + Deruxtecan) Injection 

Introduction

Enhertu Injection is an advanced targeted anti-cancer medication that combines trastuzumab (a monoclonal antibody) with deruxtecan (a chemotherapy agent). It is specifically designed to treat cancers that express the HER2 (Human Epidermal Growth Factor Receptor 2) protein, most commonly breast and gastric cancers.

This innovative therapy belongs to a class called antibody-drug conjugates (ADCs), which deliver chemotherapy directly to cancer cells, minimizing damage to healthy tissues and improving treatment outcomes.

📞 Contact Details to Place Order

💬 WhatsApp: +91 9730316395
📞 Phone: +91 9730316395
📧 Email: info@globmedindia.com

Composition and Content

Enhertu injection contains:

• Trastuzumab – Targets HER2-positive cancer cells
• Deruxtecan – A potent topoisomerase I inhibitor (chemotherapy agent)

Typical strength:

• 100 mg per vial (lyophilized powder for reconstitution)

How It Works

Enhertu works in a targeted and efficient way:

1. Trastuzumab binds to HER2 receptors on cancer cells
2. The drug enters the cancer cell
3. Deruxtecan is released inside the cell, destroying it from within
4. It may also affect nearby tumor cells (bystander effect)

How to Use

• Administered as an intravenous (IV) infusion
• Given only under the supervision of an oncologist
• Infusion typically takes 30–90 minutes
• Pre-medication may be given to reduce side effects

Dosage

• Standard dose: 5.4 mg/kg body weight
• Given once every 3 weeks (21-day cycle)
• Dose adjustments may be required based on patient tolerance and side effects

Uses (Indications)

Enhertu is used for treating:

• HER2-positive breast cancer (metastatic or unresectable)
• HER2-low breast cancer (new indication in many cases)
• Gastric (stomach) cancer
• Other HER2-expressing solid tumors (as per oncologist recommendation)

Treatments & Therapeutic Benefits

Enhertu is typically used when:

• Cancer has spread (metastatic stage)
• Previous treatments like chemotherapy or HER2 therapies have failed
• Patients need targeted therapy with better precision

Advantages

• 🎯 Highly targeted treatment (less harm to normal cells)
• 📈 Improved survival rates in HER2-positive cancers
• 💉 Convenient dosing (once every 3 weeks)
• 🔬 Effective even in heavily pre-treated patients
• ⚡ Strong “bystander effect” helps kill surrounding tumor cells

Possible Side Effects

• Nausea and vomiting
• Fatigue
• Hair loss
• Low blood counts
• Lung-related issues (Interstitial Lung Disease – serious but rare)

⚠️ Regular monitoring is essential during treatment

Storage Conditions

• Store at 2°C to 8°C (refrigerated)
• Protect from light
• Do not freeze
• Use immediately after reconstitution

Alternative Indian Brands

Currently, Enhertu (trastuzumab deruxtecan) is a highly specialized drug and:

• Limited or no direct generic versions are widely available in India yet
• Some alternative HER2-targeted therapies (not identical) include:
  • Trastuzumab (Herclon, CANMAb)
  • Ado-trastuzumab emtansine (Kadcyla alternative)
  • Pertuzumab combinations

👉 Note: These are not exact substitutes and should only be used based on oncologist advice.

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💬 WhatsApp: +91 9730316395
📞 Phone: +91 9730316395
📧 Email: info@globmedindia.com