Celginase (L-Asparaginase 5000 IU Injection)
Celginase L-Asparaginase 5000 IU Injection is a chemotherapy medicine used primarily in the treatment of acute lymphoblastic leukemia (ALL) and certain lymphoid cancers. It contains L-asparaginase, an enzyme that works by lowering the levels of asparagine—an amino acid essential for the survival of leukemia cells. By depriving cancer cells of this nutrient, Celginase helps inhibit their growth and improves the effectiveness of combination chemotherapy regimens.
This injection is administered under strict medical supervision in hospitals or oncology clinics as part of a structured cancer treatment plan.
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Composition and Content
- Active Ingredient: L-Asparaginase
- Strength: 5000 IU per vial
- Dosage Form: Injectable (lyophilized powder for reconstitution)
- Category: Anti-cancer enzyme / chemotherapy medicine
How to Use
- Administered only by trained healthcare professionals
- Given via intramuscular (IM) or intravenous (IV) injection
- Reconstituted using sterile diluent before use
- Used according to oncologist-prescribed chemotherapy protocols
- Requires monitoring for allergic or hypersensitivity reactions
Dosage
- Dosage is individualized based on body weight and medical condition
- Used in combination chemotherapy regimens
- Administered in cycles as per cancer treatment plan
- Requires regular monitoring of liver function, blood counts, and clotting factors
Uses and Treatments
Celginase L-Asparaginase Injection is indicated for:
- Acute Lymphoblastic Leukemia (ALL)
- Lymphoid malignancies (as part of chemotherapy protocols)
- Pediatric and adult leukemia treatment
- Multi-drug cancer therapy regimens
Advantages
- Targets cancer cells by depleting asparagine
- Improves treatment outcomes in leukemia patients
- Enhances effectiveness of combination chemotherapy
- Widely accepted in standard oncology protocols
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze
- Protect from light
- Use immediately after reconstitution
- Keep out of reach of children
Alternative Indian Brands for L-Asparaginase Injection
Some commonly used alternatives include:
- Leunase Injection
- Kidrolase Injection
- Asparaginase Injection IP (various manufacturers)
- Pegylated formulations like Peg-Asparaginase Injection
(Always use under oncologist supervision.)
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