Sigrima Pertuzumab 420 mg Injection
Sigrima Pertuzumab 420 mg Injection is a targeted anti-cancer medication used primarily in the treatment of HER2-positive breast cancer. It belongs to a class of drugs known as monoclonal antibodies, which specifically target cancer cells and help slow or stop their growth. Pertuzumab works by binding to the HER2 receptor on cancer cells, preventing their proliferation and survival.
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Composition and Content
- Active Ingredient: Pertuzumab
- Strength: 420 mg per vial
- Form: Injection (Intravenous Infusion)
- Class: Monoclonal Antibody (HER2 inhibitor)
How It Works
Pertuzumab targets the HER2 receptors found on certain cancer cells. By blocking these receptors:
- It prevents cancer cell growth and division
- Enhances the effect of other anti-cancer drugs like trastuzumab
- Helps the immune system destroy cancer cells
How to Use
- Administered intravenously (IV infusion) by a qualified healthcare professional
- Given in a hospital or clinical setting
- Usually combined with other medications such as trastuzumab and chemotherapy
Dosage
- Initial Dose: 840 mg IV infusion over 60 minutes
- Maintenance Dose: 420 mg every 3 weeks
- Dosage may vary depending on patient condition and doctor’s prescription
⚠️ Always follow your oncologist’s guidance strictly.
Uses
Sigrima Pertuzumab is used in:
- HER2-positive metastatic breast cancer
- Early-stage HER2-positive breast cancer (neoadjuvant/adjuvant therapy)
- Combination therapy with trastuzumab and chemotherapy
Treatment Applications
- First-line treatment for advanced breast cancer
- Pre-surgery (neoadjuvant) therapy to shrink tumors
- Post-surgery (adjuvant) therapy to prevent recurrence
Advantages
- Targeted therapy with higher specificity
- Improves survival rates when combined with other HER2 therapies
- Reduces tumor progression
- Enhances effectiveness of chemotherapy
- Well-studied and widely used in oncology
Storage Conditions
- Store in a refrigerator at 2°C to 8°C
- Do not freeze
- Keep in original packaging to protect from light
- Use immediately after dilution (as per medical guidance)
Alternative Indian Brands for Pertuzumab 420 mg
Some commonly available alternatives include:
- Perjeta (Pertuzumab) – Original brand
- Biosimilar Pertuzumab products (availability may vary in India depending on regulatory approvals and suppliers)
👉 Always consult your doctor before switching brands.
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