PEMETREX Pemetrexed 500MG Injection
PEMETREX Pemetrexed 500MG Injection is a highly effective anti-cancer medication containing Pemetrexed, a chemotherapy agent used in the treatment of various cancers, especially lung cancer and mesothelioma. It belongs to a class of drugs known as antifolate antineoplastic agents, which work by inhibiting the growth of cancer cells by disrupting their DNA and RNA synthesis.
This injection is widely prescribed by oncologists as part of combination chemotherapy or as a single-agent therapy, depending on the patient’s condition and stage of cancer.
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Composition and Content
- Active Ingredient: Pemetrexed
- Strength: 500 mg per vial
- Form: Lyophilized powder for injection
- Category: Antifolate chemotherapy drug
How to Use
- Administered intravenously (IV infusion) under medical supervision.
- Usually given in a hospital or oncology clinic setting.
- Patients are often prescribed folic acid and vitamin B12 supplements to reduce toxicity.
- Pre-medication with corticosteroids may be recommended to minimize skin reactions.
Dosage
- Standard dosage depends on:
- Body surface area (BSA)
- Type and stage of cancer
- Patient’s overall health
- Common regimen:
- 500 mg/m² IV infusion every 21 days
- Always follow the oncologist’s prescribed schedule.
Uses
PEMETREX is primarily used in the treatment of:
- Non-Small Cell Lung Cancer (NSCLC)
- Malignant Pleural Mesothelioma
- Advanced or metastatic lung cancers
- Maintenance therapy after initial chemotherapy
Treatments & Mechanism of Action
Pemetrexed works by blocking key enzymes involved in folate metabolism, such as:
- Thymidylate synthase
- Dihydrofolate reductase
This inhibition prevents cancer cells from replicating, thereby slowing or stopping tumor growth.
Advantages
- Effective against multiple cancer types
- Can be used in combination with other chemotherapy agents (e.g., cisplatin)
- Generally well-tolerated with proper supplementation
- Suitable for maintenance therapy
- Improves survival rate in lung cancer patients
Storage Conditions
- Store below 25°C
- Keep in a dry place, protected from light
- Do not freeze
- Keep out of reach of children
- Reconstituted solution should be used promptly
Alternative Indian Brands
Some commonly available alternatives of Pemetrexed in India include:
- Alimta (by Eli Lilly and Company)
- Pemnat
- Pemetrex
- Pemehope
- Pemetrol
- Chemotrex
(Consult your doctor before switching brands)
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