JAKAVI Ruxolitinib 20 MG Tablets
JAKAVI Ruxolitinib 20 mg Tablets contain Ruxolitinib, a targeted anti-cancer medication that belongs to a class of drugs known as Janus kinase (JAK) inhibitors. It works by blocking specific enzymes (JAK1 and JAK2) responsible for abnormal cell growth and immune signaling. This helps control diseases where the bone marrow produces too many abnormal blood cells or where immune responses are dysregulated.
JAKAVI is widely used in the treatment of certain blood disorders such as myelofibrosis and polycythemia vera, and it helps reduce symptoms like enlarged spleen, fatigue, night sweats, and weight loss.
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Composition and Content
- Active Ingredient: Ruxolitinib Phosphate equivalent to Ruxolitinib 20 mg
- Form: Oral Tablets
- Packaging: Typically available in blister packs (varies by manufacturer)
How to Use
- Take the tablet orally with or without food, as prescribed by your doctor.
- Swallow whole with water; do not crush or chew.
- Maintain a fixed schedule for best results.
- Regular blood tests are required during treatment to monitor response and side effects.
Dosage
- Dosage is individualized based on:
- Platelet count
- Disease condition
- Patient tolerance
- Common dosing: 5 mg to 25 mg twice daily
- Your doctor may adjust dosage based on treatment response and side effects.
Uses
JAKAVI Ruxolitinib is used for:
- Myelofibrosis (MF) – Primary or secondary
- Polycythemia Vera (PV) – when hydroxyurea is ineffective or not tolerated
- Graft-versus-host disease (GVHD) (in certain cases)
Treatments & Mechanism of Action
- Inhibits JAK-STAT signaling pathway, which is overactive in certain cancers
- Reduces:
- Abnormal blood cell production
- Inflammation and cytokine activity
- Helps shrink enlarged spleen and improve overall quality of life
Advantages
- Targeted therapy with better symptom control
- Reduces spleen size significantly
- Improves survival outcomes in some patients
- Oral medication – convenient compared to injections
- Effective in patients resistant to conventional therapies
Storage Conditions
- Store at room temperature (15°C to 30°C)
- Keep away from moisture and direct sunlight
- Keep out of reach of children
- Do not use expired tablets
Alternative Indian Brands for Ruxolitinib 20 mg
Some commonly available Indian alternatives include:
- Ruxolitib (Natco Pharma)
- Ruxohep (Zydus Cadila)
- Ruxotinib (Hetero Healthcare)
- Jaknat (Natco)
- Ruxofin (Dr. Reddy’s Laboratories)
(Availability may vary; consult a healthcare provider before switching brands.)
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