💉 IMFINZI (Durvalumab 120 mg Injection)
IMFINZI is an advanced immunotherapy medicine used in the treatment of various cancers. It contains Durvalumab, a monoclonal antibody that enhances the body’s immune system to detect and destroy cancer cells more effectively.
Developed by AstraZeneca, IMFINZI belongs to a class of drugs called immune checkpoint inhibitors, specifically targeting the PD-L1 protein.
🧪 Composition & Content
- Active Ingredient: Durvalumab
- Strength: 120 mg per vial
- Form: Sterile solution for intravenous infusion
-
Mechanism:
Durvalumab blocks PD-L1 interaction with PD-1 and CD80 receptors, restoring T-cell response against tumor cells.
⚙️ How It Works
Cancer cells often evade the immune system by expressing PD-L1. Durvalumab inhibits this pathway, allowing immune cells (T-cells) to:
- Recognize cancer cells
- Attack and destroy them effectively
🩺 Uses & Indications
IMFINZI is widely used in the treatment of:
- Non-Small Cell Lung Cancer (NSCLC)
- Extensive-Stage Small Cell Lung Cancer (ES-SCLC)
- Biliary Tract Cancer (in combination therapy)
- Hepatocellular Carcinoma (liver cancer, in some regimens)
💊 Dosage & Administration
- Route: Intravenous (IV) infusion
- Typical Dose:
- 10 mg/kg every 2 weeks OR
- Fixed dose (e.g., 1500 mg every 4 weeks depending on indication)
- Administration Time: 60 minutes infusion
- Supervision: Must be given by a qualified oncologist in a clinical setting
⚠️ Dosage varies based on patient condition, weight, and treatment protocol.
🧬 Treatment Benefits & Advantages
- Targets cancer through immune system activation
- Improves survival rates in lung cancer patients
- Less toxic compared to traditional chemotherapy
- Can be combined with other therapies
- Long-lasting response in some patients
🧊 Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze or shake
- Keep in original packaging to protect from light
- Use immediately after dilution or as directed
🇮🇳 Alternative Indian Brands / Biosimilars
Currently, Durvalumab biosimilars are limited in India due to patent and regulatory factors. However, oncologists may consider alternative immunotherapy molecules such as:
- Pembrolizumab (Keytruda alternatives)
- Nivolumab (Opdivo alternatives)
- Atezolizumab
👉 These are not exact substitutes but belong to the same PD-1/PD-L1 inhibitor class.
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IMFINZI (Durvalumab) is a breakthrough immunotherapy used in the treatment of lung cancer and other advanced malignancies. It works by strengthening the immune system to fight cancer cells effectively.
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