Enhertu Injection
Introduction
Enhertu (trastuzumab + deruxtecan) Injection is an advanced targeted anti-cancer medicine used primarily in the treatment of HER2-positive cancers. It belongs to a class of drugs known as antibody-drug conjugates (ADCs), combining a monoclonal antibody with a chemotherapy agent to deliver precise and powerful cancer treatment.
This innovative therapy works by specifically targeting HER2 receptors on cancer cells and delivering chemotherapy directly into them, minimizing damage to healthy cells and improving treatment outcomes.
📞 Contact Details to Place Order
💬 WhatsApp: +91 9730316395
📞 Phone: +91 9730316395
📧 Email: info@globmedindia.com
Composition and Content
- Active Ingredient: Trastuzumab Deruxtecan
- Strength: Commonly available as 100 mg vial
- Form: Lyophilized powder for reconstitution (Injection)
- Class: HER2-directed antibody-drug conjugate
How It Works (Mechanism of Action)
Enhertu combines:
- Trastuzumab – targets HER2 receptors on cancer cells
- Deruxtecan – a potent chemotherapy agent
Once bound to cancer cells, the drug enters the cell and releases chemotherapy internally, causing DNA damage and cancer cell death.
Uses
Enhertu is used in the treatment of:
- HER2-positive breast cancer (metastatic/unresectable)
- HER2-low breast cancer (advanced cases)
- Gastric (stomach) cancer with HER2 positivity
- Other HER2-expressing solid tumors (based on oncologist advice)
Dosage and Administration
- Administered intravenously (IV infusion) by a healthcare professional
- Typical dosage:
- 5.4 mg/kg body weight every 3 weeks (breast cancer)
- Dose may vary depending on condition and patient response
⚠️ Always follow your oncologist’s prescription.
How to Use
- Given in a hospital or clinical setting
- Infusion duration:
- First dose: ~90 minutes
- Subsequent doses: ~30 minutes (if tolerated)
- Regular monitoring required (blood tests, lung function, etc.)
Treatment Benefits
- Highly targeted therapy for HER2 cancers
- Improved survival rates in advanced cancers
- Effective even in patients resistant to other HER2 therapies
- Reduced systemic toxicity compared to traditional chemotherapy
Advantages
- Precision targeting of cancer cells
- Better efficacy in HER2-low cancers
- Fewer side effects on healthy tissues
- Suitable for heavily pretreated patients
Possible Side Effects
- Nausea and vomiting
- Fatigue
- Hair loss
- Low blood counts
- Lung-related toxicity (interstitial lung disease – requires monitoring)
⚠️ Immediate medical attention is required if breathing issues occur.
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze
- Protect from light
- Use immediately after reconstitution or as directed
Alternative Indian Brands
Currently, Enhertu (trastuzumab deruxtecan) is a patented and highly specialized drug.
- No widely available generic Indian brands yet
- Some hospitals may provide biosimilar HER2 therapies, but not exact substitutes
Possible Alternatives (Therapeutic Class Alternatives)
- Trastuzumab (Herceptin biosimilars)
- T-DM1 (Ado-trastuzumab emtansine)
👉 These alternatives differ in mechanism and effectiveness—consult an oncologist before switching.
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💬 WhatsApp: +91 9730316395
📞 Phone: +91 9730316395
📧 Email: info@globmedindia.com