Elaxim Recombinant Tissue Plasminogen Activator 40mg Injection
Elaxim Recombinant Tissue Plasminogen Activator (rtPA) 40mg Injection is a thrombolytic (clot-busting) medication used in emergency medical conditions to dissolve dangerous blood clots in the body. It contains Alteplase, a recombinant form of tissue plasminogen activator that helps restore blood flow by converting plasminogen into plasmin, which breaks down fibrin clots.
This life-saving injection is commonly used in acute conditions such as ischemic stroke, myocardial infarction (heart attack), and pulmonary embolism, where rapid clot dissolution is critical to prevent organ damage and improve survival outcomes.
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Composition and Content
- Active Ingredient: Alteplase (Recombinant Tissue Plasminogen Activator)
- Strength: 40 mg per vial
- Form: Lyophilized powder for injection
- Packaging: Single vial with sterile diluent (if provided)
How to Use
- Administered intravenously (IV) under strict medical supervision.
- The powder must be reconstituted with sterile water before use.
- Given in a hospital or emergency care setting by trained healthcare professionals.
- Dosage and infusion rate depend on the condition being treated.
Dosage
Dosage varies based on indication:
- Acute Ischemic Stroke:
- 0.9 mg/kg (maximum 90 mg)
- 10% given as bolus, remainder infused over 60 minutes
- Myocardial Infarction (Heart Attack):
- Accelerated infusion regimen (varies by protocol)
- Pulmonary Embolism:
- Typically 100 mg over 2 hours (adjusted as needed)
⚠️ Always follow physician-prescribed dosing guidelines.
Uses
Elaxim 40mg Injection is used for:
- Acute ischemic stroke
- ST-elevation myocardial infarction (STEMI)
- Massive pulmonary embolism
- Clearing blocked central venous catheters
Treatments Supported
- Emergency stroke management
- Cardiac care in heart attacks
- Critical care for thromboembolic disorders
- ICU and emergency hospital settings
Advantages
- Rapid clot dissolution
- Improves survival rates in emergencies
- Reduces long-term complications like paralysis after stroke
- Highly targeted action on fibrin clots
- Proven efficacy in life-threatening conditions
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Protect from light
- Do not freeze
- Use immediately after reconstitution or as per guidelines
Alternative Indian Brands (Alteplase Injection)
Some commonly available Indian or globally marketed alternatives include:
- Actilyse Injection (Alteplase)
- Alteplase by Cadila Healthcare
- Alteplase by Reliance Life Sciences
- Alteplase formulations by Biocon (availability varies)
⚠️ Availability may vary depending on region and regulatory approvals.
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