Spegra is a fixed-dose combination antiretroviral medicine used for the treatment of HIV-1 infection. It contains three powerful agents—Dolutegravir (integrase inhibitor), Emtricitabine, and Tenofovir Alafenamide (NRTIs)—which work together to reduce viral load and improve immune function.
Uses
- Treatment of HIV-1 infection in adults and adolescents
- Helps in viral suppression
- Prevents progression to AIDS
- Improves CD4 cell count
- Used as part of combination antiretroviral therapy (ART)
Dosage
- Recommended Dose: One tablet once daily
- Take with or without food
- Follow doctor’s prescription strictly
- Do not skip doses to avoid resistance
Treatment Benefits
- Long-term management of HIV infection
- Reduces risk of HIV transmission
- Maintains immune system health
- Convenient single-tablet regimen
- Lower toxicity compared to older tenofovir formulations
Advantages
- High efficacy in viral suppression
- Better kidney and bone safety profile (due to Tenofovir Alafenamide)
- Once-daily dosing improves adherence
- Fewer drug interactions (Dolutegravir-based regimen)
- Suitable for first-line HIV therapy
Storage Conditions
- Store below 25°C
- Keep in a dry and cool place
- Protect from moisture and direct sunlight
- Keep out of reach of children
Alternative Indian Brands
(Containing similar or related antiretroviral combinations)
- Taficita / TAF-based combinations (Mylan, Hetero)
- Instgra + Tafnat + Emtriva (separate combination use)
- Viropil (Dolutegravir + Lamivudine + Tenofovir DF) – Cipla
- Tavin EM (Tenofovir Alafenamide + Emtricitabine)
- Dolutegravir 50mg (Instgra – Hetero) (as a substitute component)
- *Intelavir 50 (Dolutegravir) – alternative for integrase inhibitor
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Conclusion
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