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REPATHA (Evolocumab 140 mg/mL) Injection

Evolocumab is a monoclonal antibody belonging to the PCSK9 inhibitor class, used to significantly reduce LDL cholesterol (bad cholesterol) in patients with high cardiovascular risk. REPATHA (Evolocumab 140 mg/mL) Injection helps the liver remove more LDL cholesterol from the bloodstream, lowering the risk of heart attack, stroke, and other cardiovascular complications.

It is commonly prescribed for:

• Primary hyperlipidemia
• Familial hypercholesterolemia (genetic high cholesterol)
• Patients with established cardiovascular disease requiring additional LDL reduction

This medicine is administered as a subcutaneous injection under medical supervision.

Contact Details for Orders

💬 WhatsApp: +91 9730316395
📞 Phone: +91 9730316395
📧 Email: info@globmedindia.com

Composition and Content

• Active Ingredient: Evolocumab
• Strength: 140 mg/mL
• Dosage Form: Pre-filled syringe / auto-injector pen
• Category: PCSK9 inhibitor (biologic lipid-lowering therapy)

How It Works (Mechanism of Action)

Evolocumab works by:

• Blocking the PCSK9 protein in the blood
• Increasing LDL receptor recycling in the liver
• Enhancing removal of LDL cholesterol from the bloodstream
• Producing strong and sustained LDL reduction

Uses and Treatments

REPATHA (Evolocumab) Injection is used for:

• High LDL cholesterol (hypercholesterolemia)
• Familial hypercholesterolemia (genetic disorder)
• Patients not responding adequately to statins
• Prevention of cardiovascular events (heart attack and stroke)
• Secondary prevention in patients with heart disease

Dosage and How to Use

• Given as a subcutaneous injection
• Common dosing:
  • 140 mg every 2 weeks OR
  • 420 mg once monthly
• Injection sites: abdomen, thigh, or upper arm
• Must be administered under medical supervision

⚠️ Do not self-adjust dosage without physician advice.

Advantages

• Powerful LDL cholesterol reduction (up to 60%+)
• Reduces risk of heart attack and stroke
• Effective for statin-intolerant patients
• Convenient dosing schedule (biweekly or monthly)
• Proven cardiovascular benefit in long-term studies

Storage Conditions

• Store at 2°C to 8°C (refrigerated)
• Do not freeze
• Keep in original carton
• Allow to reach room temperature before use
• Protect from light and heat

Alternative Brands / Similar Medicines

Currently, Evolocumab is mainly available as:

• Repatha – by Amgen

Other PCSK9 and lipid-lowering alternatives include:

• Praluent (Alirocumab) – by Sanofi
• Leqvio (Inclisiran) – by Novartis

These are prescribed based on lipid profile and cardiology assessment.

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