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PEMETREX Pemetrexed 500MG Injection

Introduction

PEMETREX Pemetrexed 500MG Injection is a chemotherapy medication used in the treatment of certain types of cancer. It contains Pemetrexed, an antifolate agent that works by interfering with cancer cell growth and replication. This injection is commonly prescribed for patients with Non-Small Cell Lung Cancer and Malignant Pleural Mesothelioma, helping to slow or stop tumor progression.

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Composition and Content

Active Ingredient: Pemetrexed disodium
Strength: 500 mg per vial
Form: Lyophilized powder for injection
Class: Antifolate chemotherapy agent

How to Use

Administered intravenously (IV) under medical supervision
Usually given in a hospital or oncology clinic
Requires pre-medication such as:
- Folic acid
- Vitamin B12
- Corticosteroids
Must be prepared and diluted by a trained healthcare professional

Dosage

Typical dose: 500 mg/m² body surface area
Given once every 21 days (3-week cycle)
Dosage may vary based on:
- Patient condition
- Kidney function
- Combination therapy

⚠️ Always follow the oncologist’s prescription strictly.

Uses

PEMETREX is widely used in the treatment of:

Advanced non-small cell lung cancer (NSCLC)
Malignant pleural mesothelioma
Maintenance therapy after initial cancer treatment
Combination therapy with drugs like cisplatin

Treatments & Mechanism

Pemetrexed works by blocking enzymes involved in DNA and RNA synthesis, which are essential for cancer cell survival. This leads to:

Inhibition of tumor growth
Prevention of cancer cell division
Slowing disease progression

Advantages

Effective in multiple cancer types
Well-tolerated compared to some older chemotherapies
Can be used in combination or as maintenance therapy
Improves survival rates in certain cancers
Less severe side effects with vitamin supplementation

Storage Conditions

Store below 25°C
Keep in a dry place, away from light
Do not freeze
Keep out of reach of children
Use immediately after reconstitution

Alternative Indian Brands of Pemetrexed 500MG

Here are some commonly available Indian alternatives:

Pemnat – Natco Pharma
Pemetrex – Fresenius Kabi India
Alimta – Eli Lilly (original brand)
Pemetrexed for Injection – Dr. Reddy’s Laboratories
Cytotrox Pemetrexed – Hetero Healthcare

These brands offer similar efficacy and are widely exported globally.