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Olvorin Leucovorin 300 mg Injection

Introduction

Olvorin Leucovorin 300 mg Injection is a supportive anticancer medication used to enhance the effectiveness of chemotherapy and reduce its toxic side effects. It contains Leucovorin Calcium (Folinic Acid), a reduced form of folic acid that helps protect healthy cells from damage caused by certain chemotherapy drugs.

It is widely used in oncology treatments, particularly in combination with drugs like methotrexate and fluorouracil.

Composition & Content

Active Ingredient: Leucovorin Calcium (Folinic Acid)
Strength: 300 mg per vial
Form: Injection (IV/IM use)
Category: Antidote / Chemoprotective agent / Antimetabolite adjunct

Leucovorin is not a chemotherapy drug itself but plays a crucial role in improving treatment outcomes and minimizing toxicity.

How to Use

Administered intravenously (IV) or intramuscularly (IM) by a qualified healthcare professional.
Dosage and schedule depend on:
- Type of chemotherapy
- Patient’s body surface area
- Clinical condition

⚠️ Important: Self-administration is not recommended.

Dosage

Typical dosage varies based on indication:

Methotrexate Rescue Therapy:
- 10–15 mg/m² every 6 hours (adjusted based on toxicity levels)
With 5-Fluorouracil (5-FU):
- 200–500 mg/m² IV infusion
Folate Deficiency (rare cases):
- As prescribed by the doctor

Always follow oncologist instructions strictly.

Uses & Treatments

Primary Uses:

Rescue therapy after high-dose methotrexate
Enhances effectiveness of 5-Fluorouracil (5-FU) in cancer treatment
Treatment of colorectal cancer

Other Medical Uses:

Management of folic acid deficiency
Treatment of drug-induced toxicity

Mechanism of Action

Leucovorin works by:

Protecting normal cells from harmful effects of chemotherapy
Enhancing the binding of 5-FU to cancer cells, increasing its effectiveness

Advantages

Reduces chemotherapy toxicity
Improves survival rates in colorectal cancer
Supports healthy cell recovery
Enhances anticancer drug activity
Well-tolerated with minimal side effects

Storage Conditions

Store at 2°C to 8°C (refrigerated)
Protect from light
Do not freeze
Keep out of reach of children

Alternative Indian Brands for Leucovorin Injection

Some commonly available Indian alternatives include:

Leucovorin Calcium Injection – Celon Labs
Folinic Acid Injection – Samarth Life Sciences
Leucovorin by Neon Laboratories
Folvite / Folinic Acid brands (various manufacturers)
Leucorin Injection – Zydus Cadila

⚠️ Availability may vary depending on region and regulatory approvals.