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IMFINZI (Durvalumab 500 mg Injection)

IMFINZI is an advanced immunotherapy medicine used in the treatment of various cancers. It contains Durvalumab, a monoclonal antibody that helps the body’s immune system recognize and attack cancer cells more effectively.

Durvalumab belongs to a class of drugs called immune checkpoint inhibitors, specifically targeting the PD-L1 protein, which tumors use to evade immune detection. By blocking this pathway, IMFINZI boosts the immune response against cancer.

Composition & Content

Active Ingredient: Durvalumab
Strength: 500 mg per vial
Form: Sterile solution for intravenous infusion
Excipients: Histidine, sucrose, polysorbate, water for injection (stabilizing agents)

How It Works

Durvalumab blocks the interaction between PD-L1 on tumor cells and PD-1 receptors on T-cells. This mechanism enhances the immune system’s ability to detect and destroy cancer cells.

How to Use

Administered only by a qualified healthcare professional
Given as an intravenous (IV) infusion over ~60 minutes
Not for self-administration
Patients are monitored during infusion for any reactions

Dosage

Dosage depends on body weight and treatment plan:

Standard dose:
- 10 mg/kg every 2 weeks OR
- Fixed dose: 1500 mg every 4 weeks (as prescribed)
Duration depends on cancer type and patient response

⚠️ Always follow oncologist guidance strictly.

Uses & Treatments

IMFINZI is used in treating:

Non-Small Cell Lung Cancer (NSCLC)
Small Cell Lung Cancer (SCLC)
Biliary Tract Cancer
Other PD-L1 expressing tumors (as prescribed)

It is often used:

After chemotherapy/radiotherapy
In advanced or metastatic cancer stages

Advantages

Enhances natural immune defense
Targeted therapy with better precision
Improves survival rates in certain cancers
Can be combined with chemotherapy
Fewer side effects compared to traditional chemotherapy (in some cases)

Storage Conditions

Store at 2°C to 8°C (refrigerated)
Do not freeze
Protect from light
Keep in original packaging
Use immediately after dilution

Alternative Indian Brands (Durvalumab)

Durvalumab is a highly specialized biologic, so availability of exact generics is limited. However, alternatives in the same immunotherapy class include:

Pembrolizumab
Nivolumab
Atezolizumab

These are widely used immune checkpoint inhibitors available in India through authorized distributors.

Conclusion

IMFINZI (Durvalumab 500 mg Injection) represents a major advancement in cancer treatment through immunotherapy. It helps the immune system fight cancer more effectively and is widely used for lung and other cancers. Due to its targeted action and improved outcomes, it is becoming a preferred option in oncology treatment plans worldwide.