Elaxim Recombinant Tissue Plasminogen Activator 40 Mg
Elaxim Recombinant Tissue Plasminogen Activator 40 is a thrombolytic (clot-dissolving) medication used in emergency medical conditions where blood clots block vital blood flow. It contains recombinant tissue plasminogen activator (rtPA), a bioengineered protein that helps dissolve clots by converting plasminogen into plasmin, the enzyme responsible for breaking down fibrin.
This life-saving injection is commonly used in conditions such as acute ischemic stroke, myocardial infarction (heart attack), and pulmonary embolism. Early administration is critical to restore blood circulation and prevent severe complications or death.
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Composition and Content
- Active Ingredient: Recombinant Tissue Plasminogen Activator (rtPA) – 40 mg
- Formulation: Lyophilized powder for injection
- Diluent: Sterile water for reconstitution
How to Use
- Administered intravenously (IV) under strict medical supervision
- Reconstitute with sterile water before administration
- Given as a bolus dose followed by infusion, depending on indication
- Must be used in a hospital or emergency care setting only
Dosage
Dosage varies based on the condition being treated:
- Acute Ischemic Stroke:
0.9 mg/kg (maximum 90 mg) over 60 minutes - Myocardial Infarction (Heart Attack):
Accelerated infusion regimen (based on body weight) - Pulmonary Embolism:
Typically 100 mg over 2 hours (adjusted protocol)
⚠️ Dosage should always be determined by a qualified physician.
Uses
Elaxim rtPA 40 mg is used in the treatment of:
- Acute ischemic stroke
- Acute myocardial infarction (heart attack)
- Pulmonary embolism (PE)
- Catheter clearance in blocked IV lines
Treatment Applications
- Emergency thrombolysis
- Restoration of blood flow in blocked arteries
- Prevention of permanent tissue damage
- Reduction in mortality and disability rates
Advantages
- Rapid clot dissolution
- Improves survival in critical conditions
- Minimizes long-term disability (especially in stroke patients)
- Widely accepted and clinically proven thrombolytic therapy
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Protect from light
- Do not freeze
- Use immediately after reconstitution
Alternative Indian Brands
Some commonly available alternatives to Elaxim rtPA include:
- Actilyse (Alteplase)
- Alteplase Injection (generic versions)
- Tenecteplase brands (e.g., Metalyse, Elaxim TNK – though pharmacologically modified)
(Note: Substitution should only be done under medical guidance.)
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