Celginase (L-Asparaginase 5000 IU Injection)
Celginase L-Asparaginase 5000 IU Injection is an anti-cancer (chemotherapy) medicine mainly used in the treatment of acute lymphoblastic leukemia (ALL) and certain lymphoid malignancies. It contains L-asparaginase, an enzyme that reduces levels of asparagine—an amino acid required by cancer cells to grow and survive. By depleting asparagine, this medicine effectively inhibits cancer cell proliferation and enhances the effectiveness of combination chemotherapy.
Celginase is administered in a clinical setting under strict supervision by oncology specialists.
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Composition and Content
- Active Ingredient: L-Asparaginase
- Strength: 5000 IU per vial
- Dosage Form: Injectable (lyophilized powder for reconstitution)
- Category: Anti-cancer enzyme / chemotherapy agent
How to Use
- Administered by a trained healthcare professional
- Given via intramuscular (IM) or intravenous (IV) injection
- Reconstituted with sterile diluent before use
- Used as per prescribed chemotherapy protocol
- Requires close monitoring for hypersensitivity reactions
Dosage
- Determined by oncologist based on body weight and disease condition
- Used in combination chemotherapy regimens
- Given in cycles depending on treatment plan
- Monitoring of liver function, clotting factors, and blood counts is essential
Uses and Treatments
Celginase L-Asparaginase Injection is used for:
- Acute Lymphoblastic Leukemia (ALL)
- Lymphoid malignancies (as per protocol)
- Pediatric and adult leukemia treatment
- Combination cancer therapy
Advantages
- Targets cancer cells by starving them of asparagine
- Improves outcomes in leukemia treatment protocols
- Enhances effectiveness of multi-drug chemotherapy
- Well-established and widely used in oncology
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze
- Protect from light
- Use immediately after reconstitution
- Keep out of reach of children
Alternative Indian Brands for L-Asparaginase Injection
Some commonly available alternatives include:
- Leunase Injection
- Kidrolase Injection
- Asparaginase Injection IP (various manufacturers)
- Pegylated forms such as Peg-Asparaginase Injection
(Use strictly under oncologist supervision.)
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