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BDFUCIL Tegafur (100mg) + Uracil (224mg) Capsules

Introduction

BDFUCIL Tegafur (100mg) + Uracil (224mg) Capsules is an oral chemotherapy medication used in the treatment of various cancers, particularly gastrointestinal cancers. It combines two active ingredients—Tegafur, a prodrug of fluorouracil (5-FU), and Uracil, which enhances the effectiveness of Tegafur by inhibiting its breakdown. This combination allows sustained anticancer activity with improved tolerability compared to traditional intravenous chemotherapy.

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Composition and Content

Each capsule contains:

Tegafur – 100 mg
Uracil – 224 mg

Mechanism of Action:

Tegafur is metabolized in the body into fluorouracil (5-FU), which inhibits DNA synthesis in cancer cells.
Uracil enhances the bioavailability of 5-FU by inhibiting the enzyme dihydropyrimidine dehydrogenase (DPD), resulting in prolonged anticancer activity.

How to Use

Take the capsule orally with water, preferably after meals.
Do not crush or chew the capsule.
Follow your oncologist’s instructions strictly.
Regular monitoring (blood counts, liver function) is required during treatment.

Dosage

Dosage is based on body surface area (BSA) and the type of cancer.
Typically administered in cycles (e.g., daily dosing for 21–28 days followed by a rest period).
Must only be taken under medical supervision.

Uses

BDFUCIL Capsules are commonly used in the treatment of:

Colorectal cancer
Gastric (stomach) cancer
Breast cancer
Head and neck cancers

Treatment Applications

Used as monotherapy or in combination with other anticancer drugs.
Suitable for patients who require oral chemotherapy instead of intravenous treatment.
Often prescribed for adjuvant therapy (post-surgery) or advanced-stage cancers.

Advantages

Oral administration (no hospital IV required)
Improved patient convenience and compliance
Sustained release of active drug in the body
Reduced side effects compared to traditional 5-FU therapy
Cost-effective alternative to IV chemotherapy

Storage Conditions

Store below 25°C in a cool, dry place.
Protect from moisture and direct sunlight.
Keep out of reach of children.
Do not use expired medication.

Alternative Indian Brands

Some commonly available alternatives with similar composition include:

UFT Capsule (Tegafur + Uracil) – by Cadila Pharmaceuticals
Tegafur-Uracil Capsules – by Dr. Reddy’s Laboratories
UFToral Capsules – by Zuventus Healthcare