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APOTINIB (Imatinib Mesylate 400 mg Tablets)

Introduction

Imatinib Mesylate 400 mg tablets, marketed as APOTINIB, are targeted anti-cancer medicines used primarily in the treatment of certain blood cancers and gastrointestinal tumors. It belongs to a class of drugs called Tyrosine Kinase Inhibitors (TKIs), which work by blocking abnormal proteins that promote cancer cell growth.

Composition & Content

Active Ingredient: Imatinib Mesylate equivalent to 400 mg Imatinib
Form: Oral tablet
Drug Class: Tyrosine Kinase Inhibitor (TKI)

Imatinib specifically inhibits proteins like BCR-ABL, c-KIT, and PDGF receptors, which are responsible for uncontrolled cancer cell proliferation.

How It Works

Imatinib blocks signals required for cancer cell growth and division. This helps:

Slow down tumor growth
Kill cancer cells gradually
Prevent disease progression

Uses & Treatments

APOTINIB 400 mg is widely prescribed for:

1. Blood Cancers

Chronic Myeloid Leukemia (CML)
Acute Lymphoblastic Leukemia (ALL) (Philadelphia chromosome-positive)

2. Solid Tumors

Gastrointestinal Stromal Tumors (GISTs)
Dermatofibrosarcoma Protuberans (DFSP)

Dosage & Administration

Recommended Dose:

Typical adult dose: 400 mg once daily
May be increased to 600–800 mg/day depending on condition and response

How to Take:

Take with a meal and a full glass of water
Swallow whole; do not crush unless advised
Take at the same time daily

Important:

Dosage must be prescribed by an oncologist
Regular monitoring of blood counts and liver function is required

Advantages of APOTINIB (Imatinib 400 mg)

Targeted therapy with high effectiveness in CML and GIST
Oral medication – no hospitalization required
Improves survival rates significantly
Generally well tolerated compared to traditional chemotherapy
Long-term disease control possible

Possible Side Effects

Common side effects may include:

Nausea, vomiting
Fluid retention (swelling)
Muscle cramps
Fatigue
Diarrhea

Serious side effects (rare):

Liver toxicity
Severe fluid retention
Low blood cell counts

Storage Conditions

Store at room temperature (20–25°C)
Keep away from moisture and direct sunlight
Keep out of reach of children
Do not use expired medicine

Alternative Indian Brands of Imatinib 400 mg

Some reliable Indian alternatives include:

Veenat 400
Imatib 400
Gleevec
Imat 400
Cytinib 400

These brands offer cost-effective alternatives with the same active ingredient.

Conclusion

APOTINIB (Imatinib Mesylate 400 mg) is a breakthrough targeted therapy that has transformed the treatment of cancers like CML and GIST. Its ability to specifically target cancer-causing proteins makes it highly effective with manageable side effects. With proper medical supervision, it provides long-term disease control and improved quality of life.