Enhertu (Trastuzumab + Deruxtecan) Injection
Enhertu is an advanced targeted cancer therapy used primarily for treating certain types of HER2-positive cancers. It is an antibody-drug conjugate (ADC), combining the precision of targeted therapy with the potency of chemotherapy. The drug works by specifically targeting cancer cells that express the HER2 protein, delivering chemotherapy directly into those cells, thereby minimizing damage to healthy tissues.
Enhertu has shown significant effectiveness in patients with breast cancer, gastric cancer, and other HER2-expressing tumors, especially in cases where previous treatments have failed.
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Composition and Content
Enhertu injection contains:
Trastuzumab Deruxtecan (a combination of monoclonal antibody + chemotherapy agent)
Trastuzumab: Targets HER2 receptors on cancer cells
Deruxtecan: A cytotoxic topoisomerase I inhibitor (kills cancer cells)
Available strength commonly:
100 mg single-dose vial (lyophilized powder for injection)
How to Use
Administered intravenously (IV infusion) by a qualified healthcare professional.
Reconstituted and diluted before administration.
Infusion duration:
First dose: ~90 minutes
Subsequent doses: ~30 minutes (if tolerated well)
Dosage
Standard recommended dose:
5.4 mg/kg body weight, given once every 3 weeks (21-day cycle)
Dose adjustments may be required based on:
Side effects
Patient tolerance
Medical condition
Uses & Treatments
Enhertu is used in the treatment of:
HER2-positive breast cancer (metastatic or unresectable)
HER2-low breast cancer
Gastric (stomach) cancer
Non-small cell lung cancer (NSCLC) with HER2 mutations (in some cases)
Advantages of Enhertu
🎯 Targeted Therapy: Directly attacks HER2-positive cancer cells
⚡ High Efficacy: Effective even after multiple prior treatments
🧬 Precision Medicine: Reduces damage to healthy cells
📉 Improved Survival Rates in advanced cancer cases
🔬 Innovative ADC Technology
Storage Conditions
Store in a refrigerator at 2°C to 8°C
Do not freeze
Protect from light
Use immediately after reconstitution (as per medical guidelines)
Alternative Indian Brands / Options
While Enhertu is a patented and highly specialized medication, exact generic alternatives may be limited. However, similar HER2-targeted therapies available in India include:
Trastuzumab (Herceptin and biosimilars)
Ado-trastuzumab emtansine (Kadcyla)
Pertuzumab combinations
Note: Always consult an oncologist before switching therapies, as these are not direct substitutes.
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