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PEMETREX Pemetrexed 500MG Injection

PEMETREX Pemetrexed 500MG Injection is a highly effective anti-cancer medication containing Pemetrexed, a chemotherapy agent used in the treatment of various cancers, especially lung cancer and mesothelioma. It belongs to a class of drugs known as antifolate antineoplastic agents, which work by inhibiting the growth of cancer cells by disrupting their DNA and RNA synthesis.

This injection is widely prescribed by oncologists as part of combination chemotherapy or as a single-agent therapy, depending on the patient’s condition and stage of cancer.

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Composition and Content

Active Ingredient: Pemetrexed
Strength: 500 mg per vial
Form: Lyophilized powder for injection
Category: Antifolate chemotherapy drug

How to Use

Administered intravenously (IV infusion) under medical supervision.
Usually given in a hospital or oncology clinic setting.
Patients are often prescribed folic acid and vitamin B12 supplements to reduce toxicity.
Pre-medication with corticosteroids may be recommended to minimize skin reactions.

Dosage

Standard dosage depends on:
- Body surface area (BSA)
- Type and stage of cancer
- Patient’s overall health
Common regimen:
- 500 mg/m² IV infusion every 21 days
Always follow the oncologist’s prescribed schedule.

Uses

PEMETREX is primarily used in the treatment of:

Non-Small Cell Lung Cancer (NSCLC)
Malignant Pleural Mesothelioma
Advanced or metastatic lung cancers
Maintenance therapy after initial chemotherapy

Treatments & Mechanism of Action

Pemetrexed works by blocking key enzymes involved in folate metabolism, such as:

Thymidylate synthase
Dihydrofolate reductase

This inhibition prevents cancer cells from replicating, thereby slowing or stopping tumor growth.

Advantages

Effective against multiple cancer types
Can be used in combination with other chemotherapy agents (e.g., cisplatin)
Generally well-tolerated with proper supplementation
Suitable for maintenance therapy
Improves survival rate in lung cancer patients

Storage Conditions

Store below 25°C
Keep in a dry place, protected from light
Do not freeze
Keep out of reach of children
Reconstituted solution should be used promptly

Alternative Indian Brands

Some commonly available alternatives of Pemetrexed in India include:

Alimta (by Eli Lilly and Company)
Pemnat
Pemetrex
Pemehope
Pemetrol
Chemotrex

(Consult your doctor before switching brands)