Regonat Regorafenib 40 mg Tablets
Introduction
Regonat Regorafenib 40 mg Tablets is an oral anti-cancer medication used in the treatment of advanced cancers that have not responded to standard therapies. It belongs to a class of drugs known as multi-kinase inhibitors, which work by blocking multiple protein kinases involved in tumor growth, angiogenesis (blood vessel formation), and cancer progression.
Regorafenib helps slow down or stop the growth of cancer cells by cutting off their blood supply and interfering with cellular signaling pathways that promote tumor survival.
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Composition and Content
- Active Ingredient: Regorafenib
- Strength: 40 mg per tablet
- Formulation: Oral tablets
- Class: Tyrosine kinase inhibitor (TKI)
How to Use
- Take the tablet orally with water, preferably after a low-fat meal.
- Do not crush, chew, or break the tablet.
- Follow the exact schedule prescribed by your oncologist.
- Typically taken for 21 days followed by a 7-day break (28-day cycle).
Dosage
- Standard Dose: 160 mg daily (4 tablets of 40 mg each) for 21 days, followed by 7 days off.
- Dose may be adjusted based on patient tolerance and side effects.
- Always follow doctor’s prescription strictly.
Uses
Regonat Regorafenib is indicated for the treatment of:
- Metastatic Colorectal Cancer (mCRC)
- Gastrointestinal Stromal Tumors (GIST) after failure of other treatments
- Hepatocellular Carcinoma (HCC) (liver cancer) after prior therapy
Treatments & Mechanism of Action
- Blocks multiple kinases including VEGFR, PDGFR, RAF kinases
- Inhibits tumor angiogenesis (blood vessel formation)
- Slows cancer cell proliferation
- Helps in disease control when other therapies fail
Advantages
- Effective in advanced-stage cancers
- Oral administration (no need for IV infusion)
- Targets multiple cancer pathways
- Improves progression-free survival in certain cancers
Storage Conditions
- Store at room temperature (20°C to 25°C)
- Keep away from moisture and direct sunlight
- Keep out of reach of children
- Do not use expired tablets
Alternative Indian Brands for Regorafenib 40 mg
Some commonly available alternatives include:
- Regonat (Natco Pharma)
- Regorafenib by Bayer (Stivarga – original brand)
- Other generic versions from reputed Indian manufacturers
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