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OXALIMAX Oxaliplatin 100 mg Injection

OXALIMAX Oxaliplatin 100 mg Injection is a chemotherapy medication used in the treatment of various cancers, primarily colorectal cancer. It belongs to the platinum-based class of anticancer drugs and works by interfering with the DNA of cancer cells, preventing their growth and division, ultimately leading to cell death.

Oxaliplatin is commonly administered as part of combination chemotherapy regimens such as FOLFOX (Oxaliplatin + Fluorouracil + Leucovorin), which enhances its effectiveness in treating advanced or metastatic cancers.

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Composition and Content

Active Ingredient: Oxaliplatin
Strength: 100 mg per vial
Form: Lyophilized powder for injection or ready-to-use solution
Class: Platinum-based antineoplastic agent

How to Use

Administered intravenously (IV infusion) under the supervision of an oncologist.
Usually diluted in 5% dextrose solution before infusion.
Infusion duration typically ranges from 2 to 6 hours depending on the treatment protocol.
Not to be mixed with saline solutions (chloride-containing fluids), as it may degrade the drug.

Dosage

Standard adult dosage:
- 85 mg/m² IV every 2 weeks (commonly used in FOLFOX regimen)
Dosage may vary depending on:
- Patient’s body surface area (BSA)
- Type and stage of cancer
- Patient tolerance and side effects
Dose adjustments are required in case of toxicity or neuropathy.

Uses

OXALIMAX Oxaliplatin is indicated for:

Colorectal cancer (primary use)
Metastatic colorectal cancer
Adjuvant treatment after surgical removal of tumors
Sometimes used in combination therapies for:
- Gastric cancer
- Pancreatic cancer (off-label use)

Treatments & Mechanism of Action

Oxaliplatin works by:

Forming cross-links with DNA strands
Inhibiting DNA replication and transcription
Triggering apoptosis (programmed cell death) in cancer cells

It is particularly effective when combined with other chemotherapeutic agents, improving survival rates and disease control.

Advantages

Proven efficacy in colorectal cancer treatment
Enhances outcomes when used in combination therapies
Suitable for both early-stage (adjuvant) and advanced cancers
Lower nephrotoxicity compared to older platinum drugs like cisplatin
Widely accepted in global oncology protocols

Storage Conditions

Store at 2°C to 8°C (refrigerated)
Protect from light
Do not freeze
Keep out of reach of children
Use immediately after reconstitution or as per manufacturer’s guidelines

Alternative Indian Brands for Oxaliplatin 100 mg Injection

Some commonly available Indian alternatives include:

Oxiplat 100 mg Injection
Oxaltero 100 mg Injection
Oxitan 100 mg Injection
Platikem 100 mg Injection
Oxaliplatin by major Indian pharma companies like:
- Dr. Reddy’s Laboratories
- Cipla Ltd.
- Sun Pharmaceutical Industries
- Fresenius Kabi India

(Availability may vary; always consult your oncologist or supplier before purchase.)