JAKAVI (Ruxolitinib 20 MG) Tablets
JAKAVI (Ruxolitinib 20 mg tablets) is a targeted therapy medication used in the treatment of certain blood-related disorders and cancers. It belongs to a class of drugs known as Janus kinase (JAK) inhibitors, which work by blocking specific enzymes responsible for abnormal cell growth and immune system overactivity.
Ruxolitinib helps control symptoms, reduce spleen size, and improve quality of life in patients suffering from chronic myeloproliferative disorders.
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Composition and Content
- Active Ingredient: Ruxolitinib
- Strength: 20 mg per tablet
- Form: Oral tablets
- Drug Class: Janus Kinase (JAK1 & JAK2) inhibitor
How It Works
Ruxolitinib blocks the JAK1 and JAK2 enzymes, which are involved in signaling pathways that regulate blood cell production and immune response. By inhibiting these pathways, it:
- Reduces abnormal blood cell production
- Controls inflammation
- Helps shrink enlarged spleen
Uses (Indications)
JAKAVI is commonly prescribed for:
- Myelofibrosis (MF) – including primary and secondary types
- Polycythemia Vera (PV) (especially when hydroxyurea is ineffective)
- Graft-versus-Host Disease (GVHD) (in certain cases)
Dosage and Administration
- Typical starting dose: 5 mg to 20 mg twice daily (depends on platelet count and condition)
- Taken orally with or without food
- Dosage adjustments are made based on:
- Blood counts
- Patient response
- Side effects
⚠️ Always follow the doctor’s prescription strictly. Do not self-adjust the dose.
How to Use
- Swallow the tablet whole with water
- Take it at the same time each day
- Do not crush or chew the tablet
- Regular blood tests are required during treatment
Treatment Benefits
- Reduces spleen size
- Relieves symptoms like fatigue, night sweats, and weight loss
- Improves overall survival in some patients
- Helps manage chronic inflammatory responses
Advantages of JAKAVI
- Targeted therapy with precise action
- Improves quality of life significantly
- Oral administration (no need for injections)
- Effective in patients resistant to other treatments
Possible Side Effects
- Anemia
- Low platelet count (thrombocytopenia)
- Increased risk of infections
- Headache or dizziness
⚠️ Report any unusual symptoms to your healthcare provider immediately.
Storage Conditions
- Store below 30°C
- Keep in a dry place away from direct sunlight
- Keep out of reach of children
- Do not use expired medication
Alternative Indian Brands for Ruxolitinib 20 mg
Some commonly available alternatives include:
- Ruxolitinib by Natco Pharma
- Ruxotib by Glenmark
- Jaknat by Natco
- Ruxoheal by Healing Pharma
(Availability may vary depending on region and supplier)
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