Sigrima Pertuzumab 420 mg Injection
Sigrima Pertuzumab 420 mg Injection is a targeted anti-cancer medicine used primarily in the treatment of HER2-positive breast cancer. It contains Pertuzumab, a monoclonal antibody that works by blocking HER2 receptors on cancer cells, thereby slowing or stopping their growth. It is often used in combination with other chemotherapy drugs for enhanced effectiveness.
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Composition and Content
- Active Ingredient: Pertuzumab – 420 mg
- Form: Injection (Intravenous Infusion)
- Class: Monoclonal Antibody / Targeted Therapy
How It Works
Pertuzumab targets the HER2 receptor found on some cancer cells. By blocking this receptor, it prevents cancer cells from receiving growth signals, helping to:
- Slow tumor growth
- Reduce spread of cancer
- Improve effectiveness of other chemotherapy drugs
How to Use
- Administered intravenously (IV infusion) under medical supervision
- Given in a hospital or oncology clinic
- Usually combined with other drugs like trastuzumab and chemotherapy
- Infusion duration: Typically 30–60 minutes
Dosage
- Initial Dose: 840 mg IV infusion
- Maintenance Dose: 420 mg every 3 weeks
- Duration depends on patient condition and treatment plan
⚠️ Always follow the oncologist’s prescription strictly.
Uses
Sigrima Pertuzumab is used for:
- HER2-positive metastatic breast cancer
- Early-stage breast cancer (neoadjuvant/adjuvant therapy)
- Combination therapy with trastuzumab and chemotherapy
Treatments & Combinations
Often used with:
- Trastuzumab (another HER2-targeted therapy)
- Chemotherapy agents (e.g., docetaxel)
This combination improves survival rates and treatment outcomes.
Advantages
- Targeted therapy with specific action on cancer cells
- Improves overall survival in HER2-positive patients
- Reduces tumor size effectively
- Works synergistically with other cancer drugs
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze
- Protect from light
- Keep out of reach of children
Alternative Indian Brands
Some commonly available alternatives for Pertuzumab injection include:
- Perjeta (by Roche)
- Other biosimilar versions available in India (as per oncologist recommendation)
⚠️ Always consult a doctor before switching brands.
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