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V-STRANT Fulvestrant 250MG Injection

V-STRANT Fulvestrant 250 mg Injection is an anti-cancer hormonal therapy used primarily in the treatment of hormone receptor-positive (HR+) breast cancer in postmenopausal women. It belongs to the class of estrogen receptor antagonists that work by blocking estrogen activity, thereby slowing or stopping tumor growth.

It is commonly prescribed in advanced or metastatic breast cancer, especially when the disease progresses after other hormone therapies.

Composition & Content

Active Ingredient: Fulvestrant 250 mg
Form: Intramuscular Injection (pre-filled syringe, 5 ml)
Class: Anti-estrogen / Estrogen receptor antagonist

Mechanism of Action:
Fulvestrant binds to estrogen receptors and blocks estrogen effects, reducing cancer cell growth that depends on estrogen.

Uses & Indications

Primary Uses:

Hormone receptor-positive advanced breast cancer
Metastatic breast cancer (spread to other organs)
Breast cancer progressing after hormonal therapy

Combination Therapy:

Used with targeted drugs like:
- CDK4/6 inhibitors (e.g., palbociclib, ribociclib)

Dosage & Administration

Standard Dose:
- 500 mg (2 injections of 250 mg each)
- Given on:
  - Day 1, Day 15, Day 29
  - Then once monthly
Route: Deep intramuscular injection (buttocks)
Administered by: Healthcare professional only

How to Use

Do not self-administer
Injection is given slowly (1–2 minutes per dose)
Follow oncologist’s schedule strictly
Continue treatment as long as prescribed

Benefits & Advantages

✔ Targets hormone-driven cancer effectively
✔ Slows tumor progression
✔ Can be combined with advanced targeted therapies
✔ Improves survival outcomes in metastatic cases
✔ Long-acting monthly dosing

Side Effects

Common:

Nausea, vomiting
Hot flashes
Fatigue
Injection site pain
Joint & bone pain

Serious (rare):

Liver enzyme elevation
Bleeding disorders
Breathing issues

Storage Conditions

Store at 2°C to 8°C (Refrigerated)
Do not freeze
Protect from light
Keep out of reach of children

Alternative Brands (Same Composition: Fulvestrant)

Global Brand:

Faslodex (by AstraZeneca)

Indian Brands:

Vestrant 250mg Injection
Fulvekast Injection
Fulzos 250 Injection
Fulvetrant Injection

(All contain Fulvestrant 250 mg with similar therapeutic effect)

Treatments & Clinical Role

V-STRANT is widely used in:

Endocrine therapy for breast cancer
Second-line treatment after tamoxifen or aromatase inhibitors
Combination targeted therapy regimens

It plays a crucial role in personalized cancer treatment protocols.

Conclusion

V-STRANT Fulvestrant 250 mg Injection is a highly effective hormonal therapy for advanced breast cancer. With its targeted estrogen-blocking mechanism, it significantly helps in controlling tumor growth and improving patient outcomes. It is widely trusted in oncology and available in multiple equivalent Indian brands for cost-effective treatment.