Ujvira Trastuzumab Emtansine 160 mg Injection
Ujvira Trastuzumab Emtansine 160 mg Injection is an advanced targeted anti-cancer medication used primarily in the treatment of HER2-positive breast cancer. It is an antibody-drug conjugate (ADC), which combines the targeted action of trastuzumab with a powerful chemotherapy agent (emtansine), delivering the drug directly to cancer cells while minimizing damage to healthy tissues.
Introduction
Ujvira Trastuzumab Emtansine 160 mg Injection is prescribed for patients with HER2-positive metastatic or early breast cancer, especially when previous treatments like trastuzumab and taxanes have not been fully effective. It works by targeting HER2 receptors on cancer cells and releasing chemotherapy directly inside them, improving treatment outcomes.
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Composition and Content
- Active Ingredient: Trastuzumab Emtansine (160 mg)
- Form: Lyophilized powder for injection
- Class: Antibody-Drug Conjugate (ADC)
- Combines:
- Trastuzumab – Monoclonal antibody targeting HER2 receptors
- DM1 (Emtansine) – Cytotoxic agent that destroys cancer cells
How to Use
- Administered intravenously (IV infusion) under medical supervision
- Given in a hospital or oncology clinic
- Infusion duration typically 30–90 minutes
- Not for self-administration
Dosage
- Standard dose: 3.6 mg/kg body weight
- Administered once every 3 weeks (21-day cycle)
- Dose adjustments may be required based on:
- Liver function
- Side effects
- Patient tolerance
Uses
- HER2-positive metastatic breast cancer
- Adjuvant treatment in early HER2-positive breast cancer
- Patients who have previously received trastuzumab-based therapy
Treatment Benefits
- Targeted therapy with higher precision
- Reduces damage to healthy cells
- Effective in resistant or advanced cancer cases
- Improves progression-free survival
Advantages
- Dual mechanism: targeted + chemotherapy
- Fewer systemic side effects compared to traditional chemo
- Convenient 3-week dosing schedule
- Proven efficacy in HER2-positive patients
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze
- Protect from light
- Use immediately after reconstitution or as directed
Alternative Indian Brands
Some commonly available alternatives to Ujvira include:
- Kadcyla (Trastuzumab Emtansine) – by Roche
- Biceltis / other biosimilars (availability may vary in India)
(Always consult an oncologist before switching brands.)
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