REPATHA (Evolocumab 140 mg/mL) Injection
Evolocumab is a monoclonal antibody used to significantly reduce LDL cholesterol (bad cholesterol) in patients who are unable to control cholesterol levels with diet or statins alone. REPATHA (Evolocumab 140 mg/mL) Injection is a PCSK9 inhibitor that helps the liver remove more LDL cholesterol from the blood, thereby lowering the risk of heart attack, stroke, and other cardiovascular diseases.
It is widely used in patients with:
- Primary hyperlipidemia
- Familial hypercholesterolemia (genetic high cholesterol)
- Established cardiovascular disease requiring additional LDL reduction
This medicine is given as a subcutaneous injection under medical supervision.
Contact Details for Orders
💬 WhatsApp: +91 9730316395
📞 Phone: +91 9730316395
📧 Email: info@globmedindia.com
Composition and Content
- Active Ingredient: Evolocumab
- Strength: 140 mg/mL
- Dosage Form: Pre-filled syringe / auto-injector (subcutaneous injection)
- Category: PCSK9 inhibitor (lipid-lowering biologic therapy)
How It Works (Mechanism of Action)
Evolocumab works by:
- Blocking PCSK9 protein in the bloodstream
- Increasing LDL receptor availability in the liver
- Enhancing removal of LDL cholesterol from blood
- Resulting in significant LDL reduction
Uses and Treatments
REPATHA (Evolocumab) Injection is used for:
- High LDL cholesterol (hyperlipidemia)
- Familial hypercholesterolemia (genetic condition)
- Patients not responding to statins
- Prevention of cardiovascular events (heart attack, stroke)
- Secondary prevention in heart disease patients
Dosage and How to Use
- Administered as a subcutaneous injection
- Common dosing:
- 140 mg every 2 weeks OR
- 420 mg once monthly
- Injection sites: abdomen, thigh, or upper arm
- Must be used under physician guidance
⚠️ Do not self-adjust dose without medical advice.
Advantages
- Strong LDL cholesterol reduction (up to 60% or more)
- Reduces risk of heart attack and stroke
- Suitable for statin-intolerant patients
- Long-acting dosing schedule
- Proven cardiovascular protection benefits
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze
- Keep in original packaging
- Allow to reach room temperature before injection (as per instructions)
- Protect from light and heat
Alternative Brands / Similar Medicines
Currently, Evolocumab is primarily marketed as:
- Repatha – by Amgen
Alternative cholesterol-lowering biologics include:
- Praluent (Alirocumab) – by Sanofi
- Leqvio (Inclisiran) – by Novartis
These are used based on physician evaluation and patient cholesterol profile.
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