PEMETREX Pemetrexed 100MG Injection
Introduction
PEMETREX Pemetrexed 100MG Injection is a chemotherapy medication containing Pemetrexed, widely used in the treatment of certain types of cancers, especially lung cancer and mesothelioma. It belongs to a class of drugs known as antifolate antineoplastic agents, which work by interfering with cancer cell growth and slowing down tumor progression.
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Composition and Content
- Active Ingredient: Pemetrexed Disodium
- Strength: 100 mg per vial
- Form: Lyophilized powder for injection
- Class: Antimetabolite (Antifolate)
How It Works (Mechanism of Action)
Pemetrexed inhibits key enzymes required for DNA and RNA synthesis in cancer cells. By blocking these pathways, it prevents cancer cells from multiplying, ultimately leading to their death.
How to Use
- Administered intravenously (IV) by a qualified healthcare professional.
- Given as part of a chemotherapy cycle, usually in hospital settings.
Patients are often prescribed:
- Folic acid supplements
- Vitamin B12 injections
- Corticosteroids
These help reduce side effects.
Dosage
- The dosage depends on:
- Body surface area (BSA)
- Type of cancer
- Patient’s health condition
- Typically administered once every 21 days (3-week cycle).
- Must be prescribed and monitored by an oncologist.
Uses and Treatments
PEMETREX Pemetrexed 100MG Injection is used for:
1. Non-Small Cell Lung Cancer (NSCLC)
- First-line or maintenance therapy
- Often combined with platinum-based chemotherapy
2. Malignant Pleural Mesothelioma
- Used in combination with cisplatin
Advantages
- Effective in slowing tumor growth
- Better tolerated compared to some traditional chemotherapy drugs
- Can be used as maintenance therapy
- Targeted action on cancer cell metabolism
Possible Side Effects
- Fatigue
- Nausea and vomiting
- Loss of appetite
- Low blood cell counts
- Mouth sores
- Skin rash
Note: Proper supplementation (folic acid & B12) helps reduce toxicity.
Storage Conditions
- Store below 25°C
- Keep in a dry place
- Protect from light
- Keep out of reach of children
- Use immediately after reconstitution
Alternative Indian Brands of Pemetrexed 100MG
Some commonly available alternatives in India include:
- Pemnat 100 mg Injection – Natco Pharma
- Alimta 100 mg Injection – Eli Lilly
- Pemetrex 100 mg Injection – Fresenius Kabi
- Pemeza 100 mg Injection – Zydus Cadila
- Chemotrex 100 mg Injection – Hetero Healthcare
(Always consult a doctor before switching brands.)
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