JAKAVI Ruxolitinib 5 MG Tablets
JAKAVI Ruxolitinib 5 MG Tablets contain the active ingredient Ruxolitinib, a targeted therapy used primarily in the treatment of certain blood-related cancers and disorders. It belongs to a class of medicines known as Janus kinase (JAK) inhibitors, which work by blocking specific enzymes (JAK1 and JAK2) responsible for the growth and proliferation of abnormal blood cells.
JAKAVI is widely prescribed for conditions like Myelofibrosis and Polycythemia Vera, helping reduce symptoms such as enlarged spleen, fatigue, and night sweats. It plays a crucial role in improving quality of life and controlling disease progression.
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Composition and Content
- Active Ingredient: Ruxolitinib
- Strength: 5 mg per tablet
- Form: Oral Tablets
- Category: Targeted Cancer Therapy (JAK Inhibitor)
How to Use
- Take the tablet orally with or without food as prescribed by your doctor.
- Swallow the tablet whole with water; do not crush or chew.
- Maintain a consistent schedule for best results.
- Regular blood tests are required during treatment.
Dosage
- Dosage depends on:
- Patient’s condition
- Platelet count
- Response to treatment
- Typical starting dose: 5 mg twice daily (may vary).
- Dose adjustments are common based on tolerance and blood counts.
Uses
JAKAVI Ruxolitinib is used in the treatment of:
- Myelofibrosis (MF)
- Polycythemia Vera (PV) (in patients resistant to hydroxyurea)
- Graft-versus-host disease (GVHD)
Treatments & Mechanism of Action
Ruxolitinib works by inhibiting the JAK-STAT signaling pathway, which is often overactive in certain cancers. By blocking this pathway:
- It reduces abnormal blood cell production
- Shrinks enlarged spleen
- Relieves symptoms like itching, fever, and weight loss
Advantages
- Targeted therapy with fewer side effects than chemotherapy
- Improves overall survival in some patients
- Reduces spleen size significantly
- Enhances quality of life
- Effective for patients resistant to conventional treatments
Storage Conditions
- Store at room temperature (15°C to 30°C)
- Keep away from moisture and direct sunlight
- Keep out of reach of children
- Do not use expired medication
Alternative Indian Brands for Ruxolitinib 5 mg
Some commonly available Indian alternatives include:
- Ruxolitinib by Natco Pharma
- Ruxolitinib by Dr. Reddy's Laboratories
- Ruxolitinib by Zydus Lifesciences
- Ruxolitinib by Hetero Healthcare
These brands offer cost-effective alternatives with similar efficacy.
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