JAKAVI Ruxolitinib 20 MG Tablets
JAKAVI Ruxolitinib 20 mg Tablets is a targeted anti-cancer medication containing ruxolitinib, a potent Janus kinase (JAK) inhibitor. It is primarily used in the treatment of certain blood disorders and cancers, especially myelofibrosis and polycythemia vera. By blocking abnormal signaling pathways responsible for uncontrolled cell growth, this medicine helps reduce symptoms, improve quality of life, and slow disease progression.
It is a prescription-based therapy and should only be used under the supervision of a qualified oncologist or hematologist.
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Composition and Content
- Active Ingredient: Ruxolitinib
- Strength: 20 mg per tablet
- Drug Class: Janus Kinase (JAK1 & JAK2) inhibitor
- Form: Oral Tablets
How to Use
- Take the tablet orally with or without food, as directed by your doctor.
- Swallow whole with water; do not crush or chew.
- Follow a consistent schedule (same time each day) for best results.
- Regular blood tests are required during treatment.
Dosage
- The dose depends on:
- Platelet count
- Disease condition
- Patient’s response
- Common starting dose: 5 mg to 20 mg twice daily
- Dose adjustments are made by the doctor based on tolerance and side effects.
Uses
JAKAVI Ruxolitinib 20 mg Tablets are used in the treatment of:
- Myelofibrosis (MF) – including primary MF and post-polycythemia vera MF
- Polycythemia Vera (PV) – in patients resistant or intolerant to hydroxyurea
- Graft-versus-host disease (GVHD) (in certain cases)
Treatments & Mechanism of Action
Ruxolitinib works by inhibiting JAK1 and JAK2 enzymes, which are involved in signaling pathways that regulate blood cell production and immune function. By blocking these enzymes:
- It reduces abnormal blood cell production
- Helps shrink enlarged spleen
- Relieves symptoms like fatigue, night sweats, and weight loss
Advantages
- Targeted therapy with specific mechanism of action
- Reduces spleen size effectively
- Improves overall survival and symptom control
- Oral administration (easy to take)
- Suitable for long-term management under supervision
Storage Conditions
- Store at room temperature (20°C to 25°C)
- Keep away from moisture and direct sunlight
- Keep out of reach of children
- Do not use expired medication
Alternative Indian Brands of Ruxolitinib 20 mg
Here are some commonly available Indian alternatives:
- Ruxolitinib Tablets by Dr. Reddy's Laboratories
- Ruxolitinib by Natco Pharma
- Ruxolitinib by Cipla
- Ruxolitinib by Zydus Lifesciences
(Availability may vary; consult your supplier or doctor.)
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