Enhertu (Trastuzumab + Deruxtecan) Injection
Introduction
Enhertu (trastuzumab + deruxtecan) is an advanced targeted anti-cancer medicine used primarily in the treatment of HER2-positive cancers, including breast cancer and gastric cancer. It is an antibody-drug conjugate (ADC) that combines the targeted action of trastuzumab with the potent chemotherapy agent deruxtecan, delivering cancer-killing effects directly to tumor cells while minimizing damage to healthy tissues.
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- Trastuzumab binds to HER2 receptors on cancer cells, blocking their growth signals.
- Deruxtecan, a cytotoxic agent, enters the cancer cells and destroys them from within.
This targeted approach makes Enhertu highly effective in patients who have not responded well to other HER2 therapies.
Composition and Content
- Active Ingredients:
- Trastuzumab
- Deruxtecan
- Form: Lyophilized powder for injection
- Strength: Typically available as 100 mg vial
How to Use
- Administered as an intravenous (IV) infusion under medical supervision
- Given in a hospital or oncology clinic setting
- Infusion duration usually lasts 30–90 minutes depending on tolerance
Dosage
- Standard recommended dose: 5.4 mg/kg body weight
- Given once every 3 weeks (21-day cycle)
- Dose adjustments may be required based on:
- Patient condition
- Side effects
- Doctor’s recommendation
Uses
Enhertu is used for treating:
- HER2-positive breast cancer (metastatic or unresectable)
- HER2-low breast cancer
- Gastric or gastroesophageal junction cancer
- Other HER2-expressing solid tumors (as prescribed)
Treatments & Benefits
- Effective in patients resistant to previous HER2 therapies
- Improves survival rates and disease control
- Targeted therapy reduces widespread toxicity
- Suitable for advanced-stage cancers
Advantages
- Highly targeted drug delivery system
- Strong anti-tumor activity
- Better outcomes in heavily pretreated patients
- Reduced systemic chemotherapy exposure
Possible Side Effects
- Nausea and vomiting
- Fatigue
- Hair loss
- Decreased appetite
- Low blood counts
- Serious risk: Interstitial lung disease (requires monitoring)
Storage Conditions
- Store in a refrigerator at 2°C to 8°C
- Protect from light
- Do not freeze
- Keep in original packaging until use
Alternative Indian Brands for Enhertu
Currently, trastuzumab + deruxtecan combination (Enhertu) has limited generic availability in India due to patent protection. However, alternative HER2-targeted therapies include:
- Trastuzumab-based brands:
- Herclon (Trastuzumab)
- Canmab (Trastuzumab)
- Vivitra (Trastuzumab)
- Other HER2 therapies:
- Pertuzumab combinations
- T-DM1 (Trastuzumab emtansine)
👉 Note: These are not direct substitutes but may be used depending on treatment plans.
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📞 Contact Now:
💬 WhatsApp: +91 9730316395
📞 Phone: +91 9730316395
📧 Email: info@globmedindia.com
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Conclusion
Enhertu (trastuzumab + deruxtecan) represents a breakthrough in targeted cancer therapy, offering hope to patients with HER2-positive cancers. With GlobMedIndia, you can order this life-saving medicine safely, affordably, and quickly anywhere in the world.