Celginase (L-Asparaginase 5000 IU Injection)
Celginase L-Asparaginase 5000 IU Injection is an anti-cancer medicine used primarily in the treatment of certain types of blood cancers, especially acute lymphoblastic leukemia (ALL). It contains the enzyme L-asparaginase, which works by breaking down asparagine—an amino acid that cancer cells need to survive. By depriving cancer cells of this essential nutrient, the drug helps slow or stop their growth.
Celginase is usually administered as part of combination chemotherapy under strict medical supervision in hospital or oncology settings.
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Composition and Content
- Active Ingredient: L-Asparaginase
- Strength: 5000 IU per vial
- Dosage Form: Injectable (lyophilized powder for reconstitution)
- Category: Anti-cancer enzyme / chemotherapy agent
How to Use
- Administered by a qualified healthcare professional
- Given as intramuscular (IM) or intravenous (IV) injection
- Reconstituted with sterile solution before use
- Dosage and schedule depend on treatment protocol
- Requires close monitoring during administration
Dosage
- Determined by oncologist based on body weight and condition
- Commonly used in combination chemotherapy regimens
- Frequency varies (e.g., multiple doses over treatment cycles)
- Monitoring for allergic reactions and side effects is essential
Uses and Treatments
Celginase L-Asparaginase Injection is used for:
- Acute Lymphoblastic Leukemia (ALL)
- Other lymphoid malignancies (in specific protocols)
- Pediatric and adult leukemia treatment regimens
- Combination chemotherapy for blood cancers
Advantages
- Targets cancer cells by starving them of asparagine
- Effective component of leukemia treatment protocols
- Improves treatment outcomes when used in combination therapy
- Well-established and widely used in oncology
Storage Conditions
- Store at 2°C to 8°C (refrigerated)
- Do not freeze
- Protect from light
- Use immediately after reconstitution
- Keep out of reach of children
Alternative Indian Brands for L-Asparaginase Injection
Common alternatives available in India include:
- Leunase Injection
- Kidrolase Injection
- Asparaginase Injection IP (various manufacturers)
- Pegylated forms like Peg-Asparaginase (Peg L-Asparaginase)
(Use strictly under oncologist supervision.)
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